Herpes is classified as a viral skin infection. There are two forms of the herpes simplex virus that causes infection and disease in humans. Herpes simplex virus 1 (HSV-1) is the most often responsible for labial or orofacial herpes, which causes cluster fluid-filled vesicles around the mouth and face. Less commonly, blisters form on other portions of the face. Herpes simplex-2 (HSV-2) is genital herpes that is caused by herpes simplex viruses 1 or type 2. In type 2, the infected person may have sores around the genitals or rectum. Herpes simplex type 1, which is transmitted through oral secretion or sores on the skin, can be spread through kissing or sharing things, such as: drinks, toothbrushes, or eating utensils. Herpes type 2 can only be spread through sexual contact. Symptoms of herpes simplex virus usually appear as a blister or multiple blisters on or around the mouth, genitals, or rectum. Herpes simplex virus is diagnosed by laboratory test, including DNA test and virus cultures. However, usually a physician does not need to a test to confirm diagnosis because of the appears of the blister. Herpes is a virus that cannot be cured. Once a person has the virus, it remains in the body forever. The virus lies inactive in the nerve cells until something triggers it to become active again. However, antiviral medication, such as valtrex can shorten and prevent outbreaks during the time. Valtrex should be taken twice a day, 12 hours apart. Valtrex may cause fever, headache, pain, and peripheral edema.